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| Gimenes,A.C.; Bravo,D.M.; Nápolis,L.M.; Mello,M.T.; Oliveira,A.S.B.; Neder,J.A.; Nery,L.E.. |
| Exercise intolerance due to impaired oxidative metabolism is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still uncertain whether L-carnitine supplementation is beneficial for patients with MM. The aim of our study was to investigate the effects of L-carnitine on exercise performance in MM. Twelve MM subjects (mean age±SD=35.4±10.8 years) with chronic progressive external ophthalmoplegia (CPEO) were first compared to 10 healthy controls (mean age±SD=29±7.8 years) before they were randomly assigned to receive L-carnitine supplementation (3 g/daily) or placebo in a double-blind crossover design. Clinical status, body composition, respiratory function tests, peripheral muscle strength (isokinetic and isometric torque) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise tolerance; Muscle strength; Mitochondrial myopathy; L-carnitine supplementation. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400354 |
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| Jerônimo,Fabiana S.; Alves,Giovanni N.; Cipriano Jr.,Gerson; Vieira,Paulo J.C.; Chiappa,Adriana M. Güntzel; Chiappa,Gaspar R.. |
| Background:the impact of human immunodeficiency virus type 1 (HIV-1) on lung function is well known and associated with a reduction in pulmonary ventilation. Moreover, the use of highly active antiretroviral therapy has been associated with mitochondrial dysfunction and decreased muscle strength. However, there is scarce information about the factors associated with inspiratory muscle weakness in these patients.Objective:the purpose of the present study was to investigate the factors associated with inspiratory muscle weakness in patients with HIV-1.Methods:two-hundred fifty seven patients with HIV-1 were screened and categorized into two groups: (1) IMW+ (n= 142) and (2) IMW-(n= 115). Lung function (FEV1, FVC and FEV1 /FVC), maximum inspiratory pressure,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diaphragm muscle Inflammatory response Lung function; Exercise tolerance; Highly active antiretroviral therapy Inspiratory muscle. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100001 |
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| Travassos,P.B.; Godoy,G.; De Souza,H.M.; Curi,R.; Bazotte,R.B.. |
| The aim of this study was to investigate the effect of lactatemia elevation and glycemia reduction on strenuous swimming performance in fasted rats. Three rats were placed in a swimming tank at the same time. The first rat was removed immediately (control group) and the remaining ones were submitted to a strenuous swimming session. After the second rat was exhausted (Exh group), the third one was immediately removed from the water (Exe group). According to the period of time required for exhaustion, the rats were divided into four groups: low performance (3–7 min), low-intermediary performance (8–12 min), high-intermediary performance (13–17 min), and high performance (18–22 min). All rats were removed from the swimming tanks and immediately killed by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lactic acid; Lactate/pyruvate ratio; Exercise tolerance; Exhaustion; Gluconeogenesis. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500618 |
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